Ramsey Lab

Research Goal:

The Ramsey Lab is focused on elucidating the biophysical mechanisms underlying the ability of the RIG-I-like receptors (RLRs) to sense cytosolic double-stranded RNA (dsRNA) and initiate an innate immune response by studying this family of receptors from a variety of species including avian species and scavengers such as vulture and hyenas. This approach seeks to understand the fundamental biology of RLR function across species as a way to inform on future therapeutic design for humans and beyond.

Why should we study RLRs?

RNA viruses comprise some of the most significant health threats across the world, and the innate immune system constitutes the body's first line of defense to invasions by these pathogens. The RIG-I-like receptors (RLRs) are a family of pattern recognition receptors which are responsible for sensing cytosolic double-stranded RNA (dsRNA), a highlight of viral infection, and initiating an innate immune response. Proper function of RLRs is required for a robust initial defense against viral infection. Furthermore, RLRs are a common target for vaccine adjuvant design and are even emerging as potential targets for therapeutics which sensitize certain tumors to novel immune checkpoint inhibitors. It is critical that we understand the precise biophysical mechanisms underlying RLR function in order to inform the design of therapeutics which target RLRs.